Ethyl Gallate: Promising Cytoprotective against HIV-1-Induced Cytopathy and Antiretroviral-Induced Cytotoxicity

Introduction. HIV-1 infection in cell culture is typically characterized by certain cytopathic effects such as vacuolization of cells and development syncytia, which further lead to death. In addition, the majority drugs during HIV treatment exhibit serious adverse patients, apart from their beneficial role. During screening cytoprotective agents protect HIV-1-associated death also drug-associated toxicity, antioxidants a natural source are assumed be choice. A well-known antioxidant, ethyl gallate (EG), was selected for cytoprotection studies have already been proven an anti-HIV agent. Objective. The main objective study explore potential EG against HIV-1-induced effect antiretroviral drug toxicity. Methods. DPPH free radical scavenging assay performed with find effective concentration antioxidant activity. HIV-1infection-associated rescue were studied MT-2 lymphocytes microscopic method XTT assays. cellular toxicity different lines consequent effectiveness investigated using MTT viability assay. Results. Like ascorbic acid, exhibited promising MT2 induces often referred effect. usage causes severe like cytotoxicity. this context, tested its properties drug-mediated reclaimed back Antiretroviral drugs, ritonavir, efavirinz, AZT, nevirapine, induced more at higher concentrations tissue models liver (THLE-3), lung (AEpiCM), colorectal (HT-29), brain (U87 MG). Pretreated rescued toxic doses ART. Conclusion. found not only HIV-1-linked but chemotoxicity drugs. Evidently, could supplement management AIDS along enormous benefits.